Search results for "Tumor Initiators"

Importance of Individual Enzymes in the Control of Ultimate Carcinogens

1995

The metabolic activation of most chemical mutagens and carcinogens is a prerequisite for their mutagenic and carcinogenic activity. Reactive metabolites are under the control of activating, inactivating and precursor sequestering enzymes. These enzymes are under the long-term control of induction and repression and under the short-term control of posttranslational modification. As far as carcinogen-metabolizing enzymes are concerned, posttranslational modification has received little attention. This short-term regulation may be especially important since it works fast and may affect the enzymatic activity as well as the degradation of the enzyme. The enzymatic activity is modified by activa…